Escapecraft

Melee weapons only (Swords, Spears, Flails, Chakrams & similar thrown weapons)
Difficulty: Early game *
Mid game *
Late game **

Magic only (Any item that consumes mana)
Difficulty: Early game ***
Mid game *
Late game *

Archer (Bows and repeaters only)
Difficulty: Early game *
Mid game **
Late game **

Marksman (Guns only, must consume ammo)
Difficulty: Early game ****
Mid game *
Late game *

Ninja (Shiriken, Knifes, Spiky balls, and other thrown weapons only)
Difficulty: Early game **
Mid game **
Late game ***

Explosives only (Grenades, bombs, dynamite & explosives)
Difficulty: Early game ***
Mid game **
Late game ***

Herbalist (Potions, vile powder, purification powder, holy/unholy water)
Difficulty: Early game **
Mid game **
Late game ***

Eater of worlds rush (Kill the Eater of Worlds on the first night)
Difficulty *

Jungle rush (Loot the jungle on the first night)
Difficulty **

Dungeon rush (Kill Skeletron and loot the dungeon on the first night)
Difficulty ***

Adventurer (No mining, all your loot must come from boss fights or chests. Felling trees is allowed)
Difficulty *

Imma Dwarf (After the first day you must tunnel underground with whatever supplies you've gathered. You aren't allowed back to the surface until you've activated hardmode.
Difficulty **

100hp run (Self explanatory, ignore all heart crystals)
Difficulty **

Roleplaying as a man with a cripppling fear of wealth and success (No money or chests. Bin any money you accumulate and never spend any, and leave all chests you find unopened. Your loot must be either crafted or dropped from a boss/mob)
Difficulty ***